Table 4.
Streptococcus pneumoniae resistance profile to Penicillin and Ceftriaxone in Children <5 years at the UTH Children’s Hospital, 2010–2019
| PCV10 Serotypes (n) | PEN MIC Range (µg/mL) | CRO MIC Range (µg/mL) |
|---|---|---|
| 1 (10) | 0.004 (S) to 0.06 (S) | 0.008 (S) to ≤0.5 (S) |
| 4 (1) | 1 (R) | ≤0.5 (S) |
| 6B (2) | 0.03 (S) to 0.06 (S) | ≤0.5 (S) |
| 6B (2) | 0.25 (S) to 0.5 (R) | ≤0.5 (S) |
| 7F (1) | 0.03 (S) | ≤0.5 (S) |
| 14 (1) | 0.25 (R) | 0.12 (S) |
| 14 (1) | 2 (R) | 1 (I) |
| 18C (2) | 0.08 (S) to 0.015 (S) | 0.015 (S) to 0.03 (S) |
| 19F (5) | 0.5 (R) | 0.12 (S) to ≤0.5 (S) |
| 23F (2) | 0.03 (S) to 0.25 (R) | 0.25 (S) to ≤0.5 (S) |
| Total (28) | Resistance 39% (11/28) | Intermediate 3.5% (1/28) |
| Non-PCV10 serotypes (n) | ||
| 3 | 0.12 (R) | 0.12 (S) |
| 6A (1) | 0.12 (R) | 0.25 (S) |
| 6A (1) | 0.06 (S) | ≤0.5 (S) |
| 10F | 0.06 (S) | ≤0.5 (S) |
| 15C (1) | 0.06 (S) | ≤0.5 (S) |
| 15C (2) | 0.12 (R) | ≤0.5 (S) |
| 18F (3) | 0.008 (S) | 0.015 (S) |
| 19A (1) | 0.25 (R) | ≤0.5 (S) |
| 46 (8) | 0.008 (S) to 0.015 (S) | 0.03 (S) to 0.015 (S) |
| Total (19) | Resistance 26% (5/19) | Resistance (0) |
Abbreviations: CRO, cefotaxime; MIC, minimum inhibitory concentration; PCV10, 10-valent pneumococcal conjugate vaccine; PEN, penicillin; UTH, University Teaching Hospital.
NOTE: Non-PCV10 serotypes: serotypes not covered by PCV10.