FIGURE 2.

Tumor‐derived extracellular vesicle (EVs) in cancer pathogenesis and progression. (A) EVs secreted by primary tumors are released into blood circulation and other biological fluids (cerebrospinal fluid, urine, etc.) and may represent a useful source of tumor‐derived biomarkers for early diagnosis. (B) EVs secreted by brain seeking primary tumor cells travel long distances, are transcytosed through the intact blood–brain barrier and target and modulate the basal phenotype of healthy brain parenchyma cells