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. 2021 Sep 1;131(17):e140989. doi: 10.1172/JCI140989

Figure 10. Suppression of hepatocyte Angptl4 by GalNac-conjugated Angptl4 ASO increases EE without influencing food intake.

Figure 10

(A–E) Metabolic analysis of Angptl4 ASO– and Ctrl ASO–treated HFD-fed mice over a 48-hour period. (A) Oxygen consumption. Right panel shows cumulative graph of O2 consumption. (B) Carbon dioxide production. Cumulative graph on the right. (C) EE. Right section indicates cumulative graph. (D) Total activity. (E) Food consumption. All data are represented as mean ± SEM. *P < 0.05; **P < 0.01; ***P < 0.001, comparing Angptl4 ASO– with Ctrl ASO–treated mice using an unpaired t test.