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. 2021 Sep 1;131(17):e140989. doi: 10.1172/JCI140989

Figure 4. Lack of ANGPTL4 function in hepatocytes results in improved glucose homeostasis and enhanced insulin sensitivity.

Figure 4

(A) Intraperitoneal glucose tolerance test (GTT) (1 g/kg body weight) and AUC (right panels) of mice fed an HFD for 16 weeks. (B) Intraperitoneal insulin tolerance test (ITT) (2.0 U/kg body weight) and AUC (right panels) of mice fed an HFD for 16 weeks. (C) Representative immunoblot images and quantification of Akt (Ser 473 phosphorylation status relative to total AKT) (right panels) in the liver, muscle, and AT 15 minutes after an intraperitoneal bolus of insulin (2.0 U/kg) or saline in 16-week HFD-fed WT versus Hmut mice. R.D., relative density. All data are represented as mean ± SEM. *P < 0.05; **P < 0.01, comparing Hmut with WT mice using unpaired t test.