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. 2021 Sep 1;131(17):e140989. doi: 10.1172/JCI140989

Figure 5. Genetic loss of ANGPTL4 in hepatocytes improves obesity and attenuates atherosclerosis.

Figure 5

(A) Body weight (B), plasma TAGs, and TC from overnight-fasted WT and Hmut mice fed a WD for 16 weeks. (C) Lipoprotein profile analysis of pooled plasma of overnight-fasted WT and Hmut mice (n = 5). (D) Left: representative histological analysis of a cross section of the aortic root sinus isolated from WT and Hmut mice fed a WD for 16 weeks stained with H&E (upper panels) and oil red O (lower panels). Right: quantification of plaque size and the percentage area of neutral lipid accumulation calculated from H&E or ORO cross sections, respectively. Original magnification, ×10. (E) Representative cross-section analysis of macrophage content (CD68-positive cells) of the aortic root from WT and Hmut mice fed a WD for 16 weeks. Quantifications of the graphs on the right. Original magnification, ×10. All data are represented as mean ± SEM. *P < 0.05; **P < 0.01, comparing Hmut with WT mice using the unpaired t test.