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. 2021 Sep 1;131(17):e146861. doi: 10.1172/JCI146861

Figure 1. Genetic deletion of DAGLα reduces voluntary alcohol intake.

Figure 1

(A) Schematic of the 2BC EtOH drinking paradigm for DAGLα–/– mice. In male and female DAGLα–/– (DAGLα KO) mice, (B and C) EtOH preference and (D and E) consumption were lower than in WT mice. Male DAGLα–/– maintained lower EtOH preference (B) and consumption (D) throughout the experiment, whereas females reached WT levels in both measures by week 4 (C and E). (F and G) Male and female DAGLα–/– mice showed no difference in total fluid consumption. Data analyzed by repeated-measure 2-way ANOVA, followed by a Holm-Šidák test for multiple comparisons between genotypes. Sample size n, P, and F values for main effects of genotype, and significance for post hoc multiple comparisons are reported in the graphs. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Data are presented as mean ± SEM.