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. 2021 Sep 1;131(17):e144898. doi: 10.1172/JCI144898

Figure 2. Immediate administration of exogenous IAIP reduces infarct size after MCAO in a dose-dependent manner.

Figure 2

(A) The experimental timeline. (B) Total hemispheric infarct volume measurements were determined using TTC-stained brain sections. Significant protection is seen with IAIP treatment at doses of 30 and 45 mg/kg (PBS vs. IAIP 30 mg/kg, ***P = 0.0001; PBS vs. IAIP 45 mg/kg, ****P < 0.0001; 1-way ANOVA adjusted for multiple testing). (C) Representative TTC-stained images of vehicle-treated (control) and IAIP-treated (30 mg/kg) brains from young stroke mice (90 minutes MCAO, 24 hours reperfusion) treated immediately after stroke. (D) Quantification of infarct volumes shows a significant reduction in cortex, striatum, and total hemisphere at 24 hours after stroke (vehicle vs. IAIP 30 mg/kg, mean ± SEM; ***P = 0.0004, ****P < 0.0001, 2-sample t test adjusted for multiple testing). (E) IAIP treatment significantly reduced NDS compared with vehicle treatment. Data are presented as median and interquartile range (**P = 0.0057, Wilcoxon’s rank sum test). (F) Percentage of water content in ipsilateral (Ipsi) and contralateral (Contra) hemispheres of young vehicle- and IAIP-treated mice (***P = 0.0005, t test adjusted for multiple testing).