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. 2021 Sep 1;131(17):e144898. doi: 10.1172/JCI144898

Figure 3. Delayed administration of IAIP 6 hours and 18 hours after MCAO reduces infarct volume and improves functional recovery.

Figure 3

(A) Experimental timeline illustrates the delayed dosing regimen. (B and C) Representative TTC-stained coronal sections (vehicle and IAIP) (B) with quantification data (C). Delayed administration of 30 mg/kg IAIP at 6 hours and 18 hours after MCAO significantly reduced acute infarct volumes at 48 hours after stroke in the cortex, striatum, and total hemisphere (****P < 0.0001, 2-sample t test adjusted for multiple testing). (D) In cohort 2, representative cresyl violet–stained coronal section at day 7 after stroke (vehicle and IAIP). (E) Significant protection was seen with IAIP treatment in cohort 2 on day 7 after stroke in the cortex, striatum, and total hemispheres (****P < 0.0001 by 2-sample, 2-sided t test adjusted for multiple testing). (F) IAIP treatment significantly improved functional outcomes in NDS at 48 hours (**P = 0.0061, Wilcoxon’s rank sum test). (G) IAIP treatment significantly reduced rotational bias at day 7 after stroke by corner test (*P = 0.0137, repeated-measures 2-way ANOVA adjusted for multiple testing).