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. 2021 Sep 1;131(17):e144898. doi: 10.1172/JCI144898

Figure 4. Extended delayed IAIP treatment reduces brain atrophy.

Figure 4

(A) Young male mice were randomized and subjected to stroke or sham surgery (60 minutes MCAO) followed by treatment with IAIP or vehicle and behavioral testing out to post-stroke day 30. (B) Representative images of atrophy from vehicle- and IAIP-treated groups after stroke. (C) Quantification of brain atrophy in vehicle- and IAIP-treated mice demonstrated a significant reduction in atrophy in IAIP-treated mice (***P = 0.0003, t test). (D) Both IAIP- and vehicle-treated groups had equivalent decreases in blood flow at occlusion and reperfusion, as measured by laser speckle.