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. 2021 Sep 1;131(17):e145472. doi: 10.1172/JCI145472

Figure 14. ATF6 is required for optimal clearance of S. Typhimurium upon oral infection in mice.

Figure 14

Mice given scrambled or ATF6 siRNA (i.p.) were orally inoculated with S. Typhimurium (n = 4–12). Seven days later mice were assessed. (A) Body weights. (B) Colon mRNA expression. (C) S. Typhimurium CFU in the indicated tissues. (D) Colon myeloperoxidase. (E) Fecal lipocalin. (F) Colon cytokines. Mean + SEM. NS, not significant. *P < 0.05; **P < 0.01; ***P < 0.001; †P < 1 × 10–4, ††P < 1 × 10–5 determined by 2-tailed Student’s t test.