Figure 8. IBD risk rs6426833 AA disease risk carriers demonstrate reduced PRR-induced UPR signaling.

MDMs from rs6426833 GG, GA, or AA carriers (n = 10 donors/genotype) were left untreated or treated with 100 μg/mL MDP. (A) Fold phospho-PERK and phospho-IRE1α induction at 30 minutes. (B) Fold change mRNA expression at 4 hours. Mean + SEM. **P < 0.01; ^†P < 1 × 10⁻⁴; ^††P < 1 × 10⁻⁵ determined by 2-tailed Student’s t test with a Bonferroni-Holm correction for multiple comparisons.