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. 2021 Aug 20;17(8):e1009805. doi: 10.1371/journal.ppat.1009805

Fig 1. Luteolin protects mice against tuberculosis.

Fig 1

C57BL/6 mice were challenged with H37Rv via the aerosol route with a dose inoculum of ~ 220 CFU/mice, sacrificed at various time points and lungs and spleens were harvested. Log10 CFU from the lung (A), spleen (B) and liver (C) homogenates of mice infected with H37Rv and treated with Luteolin, Isoniazid (INH) or Luteolin+INH. Data shown are representative of three independent experiments with three mice per group. Differences were considered significant at p<0.05 and are represented as following: * for Infected vs. Luteolin, * for Infected vs. INH, * for Infected vs. Luteolin+INH, * for Luteolin vs. Luteolin+INH & * for INH vs. Luteolin+INH; * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001. Gross pathology of lungs (D) and spleen (E) at 60 dpi. Granuloma-like structures are indicated by arrows. (F) Lungs were dissected out and preserved in 4% paraformaldehyde. These preserved lungs were then processed for paraffin embedding, sectioning and staining with Hematoxylin and Eosin (H&E). Granuloma-like structures are indicated by arrows.