Fig 6. Luteolin-mediated TB immunity prevents disease relapses.

M.tb infected mice were treated with Isoniazid or Isoniazid+Luteolin for 120 days and then rested for another 30 days. Then, one group was reinfected with M.tb and a second group was treated with dexamethasone for 30 days. Mice were then sacrificed for CFU estimation to determine the rate of relapse post-treatment. (A & B) Lung CFU in reinfected mice after 15 days of secondary infection. (C & D) Rate of reactivation of latent bacteria and corresponding CFU range recorded. Data shown are from a single experiment of ten mice in each group and represent the MEAN±STDEV values. Differences were considered significant at P<0.05 and are represented by * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001 whereas non-significant differences are denoted by (NS).