Table 2. Top SNPs associated with abdominal aortic aneurysm.

SNP	Chr: BP (GRCh37)	Allele	Nearest Gene	Type	MAF (%)	OR (95% CI)	P-value
rs116390453	5:27,997,008	C/T	LINC01021	Intergenic	0.77	2.505 (1.84–3.4)	4.26x10-9
rs7936928	11:130,279,168	C/T	ADAMTS8	Intronic	39.3	0.786 (0.724–0.853)	7.51x10-9
rs4936099	11:130,280,725	A/C	ADAMTS8	Intronic	40.7	0.789 (0.727–0.856)	1.05x10-8
rs11222084	11:130,273,230	A/T	ADAMTS8	Intergenic	36.7	0.785 (0.723–0.853)	1.12x10-8
rs3740888	11:130,278,210	T/C	ADAMTS8	Intronic	39.4	0.790 (0.728–0.858)	1.59x10-8
rs113626898	2:86,015,431	G/A	ATOH8	UTR3	0.59	2.714 (1.93–3.82)	9.06x10-9
rs193181528	9:5,059,543	T/C	JAK2	Intronic	0.58	2.776 (1.93–3.99)	3.26x10-8
rs1537373	9:22,103,341	G/T	CDKN2B-AS1	ncRNA	49.4	0.821 (0.76–0.887)	6.68x10-7
rs12740374	1:109,817,590	G/T	CELSR2	3’-UTR	21.8	0.767 (0.694–0.848	2.04x10-7
rs629301	1:109,818,306	T/G	CELSR2	3’-UTR	22	0.770 (0.697–0.851)	2.78x10-7
rs646776	1:109,818,530	T/C	CELSR2	downstream	22	0.770 (0.697–0.851)	2.83x10-7
rs3832016	1:109,818,158	C/CT	CELSR2	3’-UTR	21.3	0.768 (0.694–0.85)	3.35x10-7
rs660240	1:109,817,838	C/T	CELSR2	3’-UTR	21.3	0.771 (0.696–0.853)	4.36x10-7
rs7528419	1:109,817,192	A/G	CELSR2	3’-UTR	22	0.777 (0.703–0.858)	6.81x10-7

7 variants in 4 genes, LINC01021, ADAMTS8, ATOH8 and JAK2, reached genome-wide significance P-value of < 5 x10^-8, while 7 additional variants in CDKN2B-AS1 and CELSR2, while not statistically significant, replicated findings from earlier studies. Of these, LINC01021, ATOH8 and JAK2 are novel AAA-associated loci identified in the present study (bold faced). Chr:BP denotes the chromosome location and NCBI Build 37 SNP physical position. Variants that are in linkage disequilibrium (LD) are identically colored. MAF, minor allele frequency. OR, odds ratio.