Table 3. SNPs in 3 novel loci associated with thoracic aortic aneurysm.
SNP | Chr:BP | Allele | Nearest Gene | Type | MAF (%) | OR (95% CI) | P-value |
---|---|---|---|---|---|---|---|
rs149014140 | 10:68,863,297 | A/G | CTNNA3 | Intronic | 0.78 | 4.268 (2.57–7.07) | 1.82x10-8 |
rs148927240 | 14:52,239,510 | G/A | FRMD6 | Intergenic | 0.71 | 4.23 (2.55–7.01) | 2.19x10-8 |
rs78851735 | 18:74,774,680 | C/T | MBP | Intronic | 0.98 | 3.446 (2.22–5.35) | 3.79x10-8 |
CTNNA3, FRMD6 and MBP are novel TAA-associated loci identified in the present study (bold faced). Chr:BP denotes the chromosome location and NCBI Build 37 SNP physical position. MAF, minor allele frequency; OR, odds ratio.