TABLE 3.
In silico-predicted gene lethality from the top-ranked discriminant genes in k-mer-based and SNP-based classifiers listed for each antibiotic
| Antibiotic | Essential genes (rich media)a | Essential genes (glucose minimal medium only)a |
|---|---|---|
| Ampicillin | folP* | |
| Aztreonam | asd, purL | |
| Cefepime | pyrF | |
| Cefoxitin | ||
| Ciprofloxacin | murJ*, lptG, hemG, ribC, accA*, cysG, aroC, waaA, hemA, metK*, lptF | purA, pheA, hisD, hisG, purL*, hisF, dapE, panD, purM, hisI*, ilvD, iscS, thiD, hisA, hisB*, hisH*, proC, purD |
| Levofloxacin | fabG*, fabD* | hisF*, purL*, thiD* |
| Gentamicin | glmM*, cysG | cysH |
| Meropenem | lptG*, mraY*, murG*, ispA | cysJ, hisD*, pdxA, hisC*, asd, hisF*, metF, murC, iscS, hisA, hisB, hisH*, hisG |
| Tetracyline | folP, murB | |
| Tobramycin | iscS | |
| Trimethoprim | folP*, ftsI |
a
Symbol: *, genes associated with top 50 ranked features of the antibiotic AMR model. Boldface genes have not been found essential in experimental studies.