TABLE 5.
In silico-predicted essential genes on specific carbon sources from the top-ranked discriminant genes in k-mer-based and SNP-based classifiers listed for each antibiotic
| Antibiotic | Lethal genes for growth on specific carbon sources important in AMR modela |
|---|---|
| Ampicillin | gatC, mhpB |
| Aztreonam | adiC, yihP, cpdB, garD, mngB, paaK |
| Cefepime | |
| Cefoxitin | garD, kgtP, fucK*, ulaC, putA, fecA, mngB, uidB*, dgoD* |
| Ciprofloxacin | malF, ulaG, nupG*, nanE, deoA, pepD, deoC, tonB, nanA, mtlD, xylA, uxaA*, putP, speB*, mngB, cpdB, lamB |
| Levofloxacin | adiC, ttdT, uxuB, uxuA*, ttdB* |
| Gentamicin | hcaB |
| Meropenem | manZ, adiC, ulaG, exuT, fucI* |
| Tetracyline | |
| Tobramycin | |
| Trimethoprim | putP, emrE |
a
Symbol: *, genes associated with top 50 ranked features of the antibiotic AMR model.