FIG 3.

Low concentration of glucose or fructose induce rapid death of microbial cultures in stationary phase. (A) AMiGA-predicted growth curves for clinical isolates belonging to four ribotypes (two RT001 isolates, four RT027 isolates, two RT053 isolates, and three RT078 isolates) grown on minimal medium supplemented with no (0 mM), low (20 mM), or high (50 mM) concentrations of either glucose or fructose. Growth for each isolate was measured with three technical replicates. Bold lines indicate the predicted mean of growth, and bands indicate the predicted 95% credible intervals, including measurement noise. (B) Summary of differences in growth using model estimates of the area under the curve, exponential growth rate, and stationary death rate. Sampling uncertainty was summarized with the model-estimated Gaussian noise. Error bars indicate the 95% credible interval, and asterisks indicate no overlap of credible intervals between low and high conditions for each ribotype and sugar combination.