Figure 4.

WT1 inhibits AML cell proliferation in a p53-dependent Manner. (a) and (b) Cell proliferation (a) and colony formation (b) of stable HL-60 cells overexpressing full-length p53 with or without WT1 knockdown were determined by cell counting and colony-forming assay, respectively; (c) and (d). KASUMI-1 cells were transiently expressed with WT1, or p53, or both, and cell proliferation (c) and colony formation (d) were determined by cell counting and colony-forming assay, respectively. Shown are average values of triplicated results with SD; *p < 0.05; **p < 0.01; ***p < 0.001 for the indicated comparison