Figure 5.
AML-derived, WT1-binding-defective p53R248Q fails to inhibit AML cell proliferation. (a) and (b) Cell proliferation (a) and colony formation (b) of HL-60 cells overexpressing wild-type p53 or p53 (R248Q) were determined by cell counting and colony-forming assay, respectively; (c) and (d) Cell proliferation (c) and colony formation (d) of KASUMI-1 cells overexpressing wild-type p53 or p53 (R248Q) were determined by cell counting and colony-forming assay, respectively. Shown are average values of triplicated results with SD; *p < 0.05; **p < 0.01; ***p < 0.001 for the indicated comparison