Figure 6.

Chromosome 11 harbors genes for different types of diabetes. (a) Chromosome 11 of the NSY mouse possesses susceptibility genes for spontaneous type 2 diabetes, high‐sucrose induced diabetes and streptozotocin (STZ)‐induced diabetes. Control C3H mice are resistant to diabetes; whereas, NSY mice are susceptible to type 2 and STZ‐induced diabetes. Substitution of a single chromosome 11 of C3H mice with chromosome 11 from NSY mice (C3H‐Chr11^NSY) converted the diabetes‐resistant C3H mice to diabetes‐susceptible mice, indicating that chromosome 11 harbored susceptibility genes for spontaneous type 2 diabetes⁷³, high‐sucrose induced diabetes⁷⁵ and STZ‐induced diabetes⁸². (b) Location of the susceptible loci for type 1 (Idd4 in NOD mice), type 2 (Nidd1n in NSY mice) and STZ‐induced diabetes on chromosome 11. #1 The support interval of quantitative trait loci for glucose intolerance⁷². #2 Regions of impaired insulin secretion by congenic mapping under a high‐sucrose environment⁷⁵. #3 The support interval of STZ sensitivity locus in NOD mice was not clearly defined because of a limited number of markers⁸³. The centromeric and telomeric ends of the interval are therefore shown in the graduation. #4 Idd4 is now divided into several sub‐loci (Idd4.1, Idd4.2, and Idd4.3); however, each sub‐locus was mapped by multiple research groups using different strain combinations. Therefore, the interval including all these loci is shown in the closed bar. The interval of each sub‐locus is shown in the open bar.