Table 3.
Comparison of changes in clinical and neuropathy measures over a 1‐year period between patients with and without painful diabetic neuropathy
| Patients without painful diabetic neuropathy (n = 28) | Patients with painful diabetic neuropathy (n = 13) | P‐value | |
|---|---|---|---|
| ΔHbA1c (mmol/mol) | −36.6 ± 16.2 | −26.8 ± 20.2 | 0.14 |
| ΔHbA1c (%) | −3.4 ± 1.5 | −2.5 ± 1.9 | 0.14 |
| ΔTotal cholesterol (mmol/L) | −0.6 ± 0.9 | −0.7 ± 1.2 | 0.79 |
| ΔTriglyceride (mmol/L) | −0.4 ± 0.8 | −0.3 ± 0.9 | 0.72 |
| ΔHDL (mmol/L) | −0.1 ± 0.4 | 0 ± 0.3 | 0.59 |
| ΔLDL (mmol/L) | −0.4 ± 0.8 | −0.3 ± 0.8 | 0.87 |
| ΔSystolic BP (mmHg) | −4.9 ± 16.1 | 7.7 ± 18.7 | <0.05 |
| ΔDiastolic BP (mmHg) | −7.6 ± 9.6 | −3.2 ± 13.0 | 0.30 |
| ΔBodyweight (kg) | 4.0 ± 4.7 | 6.1 ± 6.3 | 0.28 |
| ΔBMI (kg/m2) | 0 ± 1.7 | 0.8 ± 1.9 | 0.24 |
| ΔDN4 score | 0.1 ± 1.1 | −0.6 ± 2.7 | 0.40 |
| ΔCNFD (fibers/mm2) | 0.2 ± 8.0 | 5.5 ± 7.4 | 0.06 |
| ΔCNBD (branches/mm2) | 14.5 ± 25.4 | 48.2 ± 46.0 | <0.05 |
| ΔCNFL (mm/mm2) | 1.2 ± 3.9 | 6.1 ± 3.8 | 0.001 |
| ΔVPT (V) | −0.2 ± 3.8 | −1.1 ± 2.8 | 0.53 |
| ΔESC feet (µS) | −2.0 ± 14.1 | −0.2 ± 14.4 | 0.77 |
Numeric variables are summarized as the mean ± standard deviation. Variables were compared using unpaired t‐test. BMI, body mass index; BP, blood pressure; DN4, Douleur Neuropathique en 4; CNBD corneal nerve branch density; CNFD, corneal nerve fiber density; CNFL, corneal nerve fiber length; ESC, electrochemical skin conductance; HbA1c, glycated hemoglobin; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; VPT, vibration perception threshold. Bold values are indicates statistically significant.