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. 2021 Feb 20;12(9):1577–1585. doi: 10.1111/jdi.13502

Figure 2.

Figure 2

Changes in the mean estimated glomerular filtration rate (eGFR) slope before and after sodium–glucose cotransporter 2 inhibitors (SGLT2is) administration, in each stage of albuminuria before SGLT2i administration. (a) The mean eGFR (mL/min/1.73 m2) over a time course of before and after administration of SGLT2is in patients with normoalbuminuria, microalbuminuria and macroalbuminuria, before SGLT2is administrations, respectively. The number of patients who have data of urinary urinary albumin/creatinine ratio (UACR) at the observational periods is shown in the lower panel of the graph of mean eGFR. Differences in changes in mean eGFR slope before and after SGLT2is administrations in each level of albuminuria before SGLT2is administrations, (b) normoalbuminuria, (c) microalbuminuria and (d) macroalbuminuria. Data are shown as the mean ± standard error (SE). ****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05; −24 to 0 months (M) vs 0–24 M.