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. 2021 Aug 2;129(6):669–683. doi: 10.1161/CIRCRESAHA.120.318577

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© 2021 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 5. — SRSF4 (serine/arginine splicing factor 4) KO mice show an increase in hypertrophy and cardiac expression of hypertrophic markers and known GR (glucocorticoid receptor) targets following DEX treatment.A and B, Echocardiography analysis of left ventricular (LV) wall thickness (A), and heart weight/body weight (B) of SRSF4 KO and control mice following 2 wk treatment with DEX (15 mg/100 g BW) or no treatment. Expression of ANF (C), brain natriuretic peptide (BNP) (D), Fkbp5 (E), and Gliz (F) was analyzed by quantitative real-time polymerase chain reaction. Data are shown as mean±SEM. Symbols represent individual animals. ***P<0.001 DEX (green) vs No DEX (violet). †P<0.05, SRSF4 KO vs control, †††P<0.001 SRSF4 KO vs control. Two-way ANOVA followed by Bonferroni correction.