Figure 10.

Chronic jetlag core clock gene transcriptomic signatures demonstrate movement toward reentrainment after normalization. Heatmap representing the differential gene expression analysis output from edgeR for each of the pancreatic core clock genes (CCGs) during early (day 1) and late (day 8/9) reentrainment. Unsupervised dendrogram clustering demonstrates a signature from chronic jetlag (CJ) male and female mice on day 1 that is different from normal circadian (NC) mice. CJ mice on day 8/9 are more similar to NC mice than CJ mice on day 9. {NCM1 = normal circadian male day 1 of normalization [zeitgeber time (ZT) 8], NCM9 = normal circadian male day 9 of normalization [ZT8], NCF1 = normal circadian female day 1 of normalization [ZT8], NCF8 = normal circadian female day 8 of normalization [ZT8], CJM1 = chronic jetlag male day 1 of normalization [ZT8], CJM9 = chronic jetlag male day 9 of normalization [ZT8], CJF1 = chronic jetlag female day 1 of normalization [ZT8], CJF8 = chronic jetlag female day 8 of normalization [ZT8]}.