Figure 12.

Reentrainment of mouse pancreas did not occur by day 9 postnormalization. The graphs represent the diurnal expression of Arntl and Per3 for normal circadian (NC; solid black) and chronic jetlag (CJ; dashed grey) mice at day 9 postnormalization. Expression was measured by quantitative real-time PCR at 4-h intervals (n = 12 per condition; 6 males/females) from zeitgeber time (ZT) 0-ZT20, and comparisons at each time point were made with Student’s t test. Differential rhythmicity testing was performed with CircaCompare, and the results are shown in the table associated with each graph. All four graphs demonstrate a statistically significant phase shift without associated changes in amplitude or mesor. ns, Not significant, ***P < 0.001, ****P < 0.0001.