Table 1.
CircaCompare differential rhythmicity analysis for the stably rhythmic male and female pancreatic core clock genes
| Male CCG | NC mesor | CJ mesor | 95% CI | Mesor P Value |
NC amplitude | CJ amplitude | 95% CI | Amplitude P Value | NC Phase | CJ Phase | 95% CI | Phase P Value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Arntl | 133.61 | 109.18 | −14.89 to 63.78 | 2.08E-01 | 180.05 | 138.71 | −14.27 to 96.98 | 1.36E-01 | 0.08 | 5.33 | −1.73 to −1.02 | 2.20E-07 |
| Clock | 587.94 | 541.21 | −14.99 to 108.3 | 1.29E-01 | 207.74 | 175.90 | −55.42 to 118.93 | 4.53E-01 | 23.81 | 4.54 | −1.70 to −0.78 | 2.27E-05 |
| Per2 | 592.34 | 524.88 | −40.66 to 175.56 | 2.06E-01 | 473.11 | 448.67 | −128.42 to 177.36 | 7.41E-01 | 15.07 | 19.46 | −1.48 to −0.82 | 9.20E-07 |
| Cry1 | 234.60 | 229.12 | −40.8 to 51.79 | 8.06E-01 | 140.08 | 128.21 | −53.6 to 77.35 | 7.08E-01 | 18.20 | 22.36 | −1.58 to −0.6 | 1.89E-04 |
| Cry2 | 328.80 | 286.08 | 9.08 to 76.43 | 1.58E-02 | 157.45 | 99.70 | 10.06 to 105.32 | 2.03E-02 | 14.93 | 20.45 | −1.85 to −1.05 | 5.12E-07 |
| Nr1d1 | 163.24 | 185.35 | −151.65 to 107.45 | 7.24E-01 | 234.35 | 285.85 | −234.69 to 131.73 | 5.62E-01 | 7.97 | 12.51 | −1.9 to −0.47 | 2.62E-03 |
| Nr1d2 | 624.21 | 503.03 | 1.16 to 241.30 | 4.81E-02 | 667.84 | 487.11 | 10.85 to 350.47 | 3.82E-02 | 10.30 | 14.98 | −1.53 to −0.92 | 1.13E-07 |
| Rorc | 425.00 | 463.30 | −146.04 to 69.41 | 4.65E-01 | 449.31 | 447.08 | −150.1 to 154.60 | 9.76E-01 | 19.19 | 0.07 | −1.62 to −0.94 | 2.97E-07 |
| Female CCG | ||||||||||||
| Arntl | 137.60 | 150.97 | −55.83 to 29.05 | 5.16E-01 | 178.10 | 150.58 | −32.52 to 87.52 | 3.48E-01 | 23.87 | 3.75 | −1.38 to 0.65 | |
| Clock | 569.36 | 654.64 | −157.69 to −12.92 | 2.35E-02 | 181.44 | 189.45 | −110.38 to 94.34 | 8.71E-01 | 0.04 | 3.57 | −1.48 to −0.37 | 2.48E-03 |
| Per1 | 771.56 | 437.39 | 213.12 to 455.27 | 1.71E-05 | 278.36 | 261.17 | −153.98 to 188.46 | 8.35E-01 | 13.94 | 17.42 | −1.54 to −0.28 | 7.51E-03 |
| Per2 | 569.77 | 463.20 | 21.3 to 191.88 | 1.72E-02 | 472.68 | 401.19 | −49.07 to 192.16 | 2.29E-01 | 15.07 | 18.93 | −1.29 to -0.73 | 5.01E-07 |
| Cry1 | 240.11 | 224.92 | −25.34 to 55.76 | 4.42E-01 | 169.76 | 156.33 | −43.93 to 70.77 | 6.29E-01 | 17.90 | 21.94 | −1.41 to −0.7 | 6.16E-06 |
| Cry2 | 325.46 | 271.15 | −1.18 to 109.72 | 5.43E-02 | 149.78 | 106.24 | −34.83 to 122.01 | 2.58E-01 | 15.14 | 19.44 | −1.76 to −0.48 | 1.66E-03 |
| Nr1d1 | 229.57 | 217.56 | −169.54 to 193.59 | 8.91E-01 | 350.18 | 328.97 | −235.54 to 278 | 8.64E-01 | 7.88 | 12.29 | −1.91 to −0.4 | 4.96E-03 |
| Nr1d2 | 675.70 | 529.14 | −25.37 to 318.22 | 8.98E-02 | 721.67 | 559.49 | −80.81 to 404.92 | 1.78E-01 | 10.26 | 14.27 | −1.44 to −0.66 | 2.18E-05 |
| Rorc | 408.07 | 450.15 | −143.04 to 58.81 | 3.93E-01 | 438.37 | 449.39 | −153.7 to 131.76 | 8.73E-01 | 19.24 | 23.63 | −1.47 to −0.83 | 5.97E-07 |
| Bhlhe40 | 194.02 | 199.58 | −38.91 to 27.74 | 7.30E-01 | 93.66 | 79.87 | −33.34 to 60.92 | 5.47E-01 | 14.00 | 18.17 | −1.64 to −0.54 | 5.57E-04 |
CCG, core clock genes; CI, confidence interval; CJ, chronic jetlag; mesor, midline estimating statistic of rhythm; NC, normal circadian.