Table 3.

Cerebrovascular and hemodynamic variables during the n-back working memory test

n-Back Working Memory Test	Young Adults	Older Adults	P Value (Effect Size)
MAP, mmHg
Control
Baseline	91 ± 13	97 ± 13	0.054 (0.49)
n-Back	94 ± 12	100 ± 12	0.046 (0.52)
Indomethacin
Baseline	92 ± 13	98 ± 14	0.066 (0.46)
n-Back	93 ± 13	100 ± 15	0.044 (0.52)
PP, mmHg
Control
Baseline	74 ± 16	77 ± 14	0.289 (0.17)
n-Back	77 ± 16	78 ± 11	0.431 (0.05)
Indomethacin
Baseline	74 ± 14	76 ± 13	0.304 (0.16)
n-Back	75 ± 14	77 ± 13	0.284 (0.17)
HR, beats/min
Control
Baseline	59 ± 7	60 ± 8	0.292 (0.17)
n-Back	67 ± 10	66 ± 11	0.282 (0.18)
Indomethacin
Baseline	56 ± 8	56 ± 8	0.494 (0.01)
n-Back	59 ± 8	60 ± 8	0.453 (0.04)
MCAv, cm/s
Control
Baseline	60 ± 14	51 ± 16	0.022 (0.63)
n-Back	64 ± 14	54 ± 16	0.022 (0.63)
Indomethacin
Baseline	44 ± 9*	38 ± 8*	0.013 (0.70)
n-Back	46 ± 9*	40 ± 9*	0.018 (0.65)
CVCi, cm/s/mmHg
Control
Baseline	0.67 ± 0.19	0.52 ± 0.17	0.004 (0.85)
n-Back	0.69 ± 0.19	0.55 ± 0.17	0.006 (0.80)
Indomethacin
Baseline	0.49 ± 0.12*	0.40 ± 0.12*	0.006 (0.79)
n-Back	0.50 ± 0.12*	0.41 ± 0.12*	0.007 (0.78)
Cerebral PI, AU
Control
Baseline	0.71 ± 0.12	0.78 ± 0.12	0.030 (0.58)
n-Back	0.67 ± 0.10	0.74 ± 0.10	0.016 (0.67)
Indomethacin
Baseline	0.85 ± 0.15*	0.90 ± 0.13*	0.147 (0.32)
n-Back	0.84 ± 0.16*	0.88 ± 0.13*	0.202 (0.26)

Values are expressed as means ± SD. Cerebral PI, cerebral pulsatility index; CVCi, cerebrovascular conductance index; HR, heart rate; MAP, mean arterial blood pressure; MCAv, middle cerebral artery blood velocity; PP, pulse pressure. P value in bold indicates a significant difference between young and older adults at baseline or in response to the n-back working memory test (independent-samples t test or Wilcoxon rank-sum test). *P < 0.05 significantly different vs. control at baseline or in response to the n-back working memory test (dependent-samples t test or Wilcoxon signed-rank test).