Figure 2.

ZP5461 produces a greater percent suppression of energy intake in HFD-fed rats compared with chow-fed rats. Percent suppression of energy intake for each dose/diet combination was calculated using energy intake under vehicle conditions for that diet. At 24 h (A), 48 h (B), and 72 h (C) postinjection, the percent suppression of energy intake by ZP5461 was greater for HFD-fed rats at all doses of drug tested (n = 13–16 per diet condition). Data were analyzed using repeated measures ANOVA with Student–Newman–Keuls post hoc analyses. Data are shown as means ± SE. *P < 0.05. HFD, high-fat diet.