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. 2021 Jul 14;321(2):R250–R259. doi: 10.1152/ajpregu.00337.2020

Figure 5.

Figure 5.

Chronic administration of ZP5461 fails to produce long-term suppression of food intake, irrespective of CTR expression in the DVC. Every 96 hours for 4 wk, animals received peripheral administration of ZP5461, first at 1nmol/kg/mL (dotted line) and then at 2 nmol/kg/mL (dashed line). A: daily noncumulative food intake measurements across 4 wk of injection treatments. B: cumulative food intake. Data represented as means ± SE. Control virus, AAV-Control; CTR knockdown virus, AAV-CTR-KD. AAV-Control, vehicle (n = 6), AAV-Control, ZP5461 (n = 7), AAV-CTR-KD, vehicle (n = 8), AAV-CTR-KD, ZP5461 (n = 9). Data analyzed by two-way ANOVA at each time point with Newman–Keuls post hoc analyses. Color of the significance symbols indicates associated cohort; * vs. AAV-Control, vehicle-treated; ^ vs. AAV-CTR-KD, vehicle-treated; # vs. AAV-Control, ZP5461-treated. CTR, calcitonin receptor; DVC, dorsal vagal complex.