Figure 1.

Effect of interferon γ (IFNγ) neutralization on mean arterial pressure (MAP) and intrauterine growth restriction in pregnant rats. On gestation day (GD) 14, the reduced uterine perfusion pressure (RUPP) procedure was performed on a subset of normal pregnant (NP) rats. On GDs 15 and 18, vehicle or 10 μg/kg of anti-IFNγ antibody was injected intraperitoneally in a subset of NP and RUPP rats. On GD 19, conscious mean arterial pressure (A) was measured and fetal weights (B), placental weights (C), and fetal resorptions (D) were recorded under isoflurane anesthesia. NP: n = 9 rats; RUPP: n = 9 rats; NP + anti-IFNγ: n = 9 rats; RUPP + anti-IFNγ: n = 9 rats. All data are expressed as mean ± SEM. Statistical analyses were performed using two-way ANOVA with multiple comparisons followed by Tukey’s post hoc test. +P < 0.05; ++P < 0.01; +++P < 0.001; ++++P < 0.0001.