Table 1.

Plasma and tissue levels of MitoQ

MitoQ Levels
Time, h	Plasma, ng/mL	Diaphragm, mcg/gm
0	0	0
4	41 ± 20	6.4 ± 3.2
8	24 ± 13	21.5 ± 3.9
24	2 ± 1	10.9 ± 7.6

Values are means ± SE. MitoQ levels in plasma and diaphragm were assessed by mass spectroscopy at 4, 8, and 24 h after administration of a single 3.5 mg/kg intraperitoneal dose (above). A tissue level of greater than 0.03 mcg/gm is considered adequate to achieve antioxidant effects in mitochondria (n = 3 animals/time point/sample). MitoQ, mitoquinone mesylate.