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. 2021 Aug 23;6(16):e150794. doi: 10.1172/jci.insight.150794

Figure 2. The intact reservoir is substantial in naive T cells of CPs but largely contained by memory cells in ECs.

Figure 2

(A) Contribution of T cell subsets to the intact reservoir of CPs 2–3 years after ART initiation (n = 5). Naive cells represented a major contributor to the intact reservoir, with a median contribution of 39% (IQR, 12%–53%), followed by Tcm cells (20% [IQR, 13%–55%]) >Ttm cells (6% [IQR, 0%–42%]) >Tem cells (3% [IQR, 0.005%–21%]). (B) Contribution of T cell subsets to the intact reservoir of ECs (n = 4). Naive T cells did not contain any intact HIV sequence. Ttm cells were the major contributor to intact HIV in ECs (86% [IQR, 32%–98%]). No intact HIV sequences were found in Tcm cells and Tem cells of 2 ECs (gray symbols). EC1 was excluded because we did not retrieve any intact HIV sequence. The contribution of each subset to the intact reservoir was calculated using the following formula: [(levels of HIV DNA within subset) × (% intact HIV within subset) × (subset/μL/total CD4/μL)]. Lines represent median values. ART, antiretroviral therapy; CPs, chronic progressors; ECs, elite controllers; naive T cells, naive CD4+ T cells; Tcm, central memory CD4+ T cells; Ttm, transitional memory CD4+ T cells; Tem, effector memory CD4+ T cells.