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. 2021 Aug 23;6(16):e149819. doi: 10.1172/jci.insight.149819

Figure 4. CD7-KO T cells are phenotypically and functionally distinct from CD7– T cells.

Figure 4

(A) CD4 and CD8 expression on T cells generated from control or CD7-KO HSCs engrafted in NSGS mice (n = 22–24/group). (B) CD4 expression on CD7+ or CD7– T cells derived from control or CD7-KO HSCs (n = 15/group). (C) Naive cells (CCR7+CD45RO–) within the CD7+ and CD7– T cell fractions in control or CD7-KO T cells (n = 10/group). (D) Human T cells derived from control or CD7-KO HSCs were expanded in vitro with anti-CD3/CD28 beads (n = 6/group) (E) CD7 expression at baseline and 3 days after activation in control and CD7-KO T cells (n = 5/group). Statistical analyses were performed using unpaired 2-tailed Student’s t test (A and D) or paired Student’s t test (B and C). *P < 0.05, **P < 0.01.