Figure 5. Receiver operating characteristic (ROC) curves areas and AUC for composite models for spontaneous preterm birth predictions.

(A–F) sPTB37 (A–C) and sPTB34 prediction (D–F) (total number of samples, n = 618; n = 425 samples from White women, n = 132 from Black women, and n = 61 from women reporting other ethnicities; n = 306 from 10–15⁺⁶ weeks or n = 312 from 16–23⁺⁴ weeks). (A–C) a model using a composite of 7 cervicovaginal fluid (CVF) metabolites performs equally for prediction of sPTB37 when stratified by ethnicity and gestation of CVF sampling (10–15⁺⁶ weeks or 16–23⁺⁴ weeks). (D and E) For sPTB34, a model of 3 CVF metabolites and CVF L. crispatus and L. acidophilus proportions shows differences in performance when stratified by ethnicity. (F) sPTB34 model performs similarly when testing samples taken between 10–15⁺⁶ or 16–23⁺⁶ weeks.