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. 2021 Aug 23;6(16):e151551. doi: 10.1172/jci.insight.151551

Figure 1. ACE2 protein expression in NHP pancreata.

Figure 1

(A) Representative confocal immunofluorescence (IF) images of pancreatic islets from uninfected male and female NHPs. Insets show colocalization of insulin (INS) with angiotensin-converting enzyme 2 (ACE2) (green arrows) and glucagon (GCG) with ACE2 (yellow arrows). (B) Representative IF images of pancreatic islets from SARS-CoV-2–infected male and female NHPs. Insets show colocalization of INS with ACE2 (green arrows) and GCG with ACE2 (yellow arrows). (C) Quantification of β cells expressing ACE2 and (D) α cells expressing ACE2 across NHPs. (E) Representative IF images of ACE2 expression in large ducts of control NHP and (F) SARS-CoV-2–infected pancreas (inset, yellow arrows). (G) Quantification of large duct–derived ductal cells expressing ACE2. (H) Representative IF images of ACE2 expression in small ducts in control and (I) SARS-CoV-2–infected NHP pancreas. (J) Quantification of small pancreatic duct–derived ductal cells expressing ACE2. Experiments represent n = 3 to 5 biological replicates. Bar graphs show the mean ± SD. Scale bars: 25 μm. ****P < 0.0001 by 1-way ANOVA with post hoc Tukey’s multiple comparison test (C, D, G, and J).