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. 2021 Jul 8;6(13):e140028. doi: 10.1172/jci.insight.140028

Figure 2. Putatively peanut-specific CDR3β sequences demonstrate increased similarity and decreased diversity when compared with total activated and resting CDR3βs.

Figure 2

(A and B) Minimum Hamming and Levenshtein distance of putatively peanut-specific CDR3β sequences (ps-CDR3s) compared with 100 equal-sized random resamplings of total activated and resting CDR3βs (**P < 0.01, ps-CDR3 vs. resting and ps-CDR3 vs. activated, Fisher’s exact test). (C) Smoothed Hill’s diversity curve at diversity orders 0–4 for 6 individuals. Diversity of ps-CDR3s was significantly lower than that of activated and resting CDR3βs at all diversity orders (P < 0.01, empirical cumulative distribution function of bootstrap delta distribution, see Methods). (D) Fold change of Hill’s diversity metric of resting/ps-CDR3s, activated/ps-CDR3s, and resting/activated CDR3βs. Distributions represent values from 25 individuals with >30 unique ps-CDR3s (**P < 0.01, Wilcoxon matched-pairs signed-rank test).