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. 2021 Jul 22;6(14):e150052. doi: 10.1172/jci.insight.150052

Figure 9. Effects of taVNS on autonomic function and its correlation with CSBMs/week, VAS score, and plasma 5-HT level.

Figure 9

taVNS enhanced vagal activity compared with sham-taVNS, as well as compared with baseline after treatment (A). (B–D) HF was positively correlated with CSBMs/week (B) and negatively correlated with VAS score (C) and plasma 5-HT level (D). The independent sample t test was used to assess the difference between the sham-taVNS and taVNS groups. The paired Student’s t test was applied to evaluate the differences before and after the taVNS or sham-taVNS treatment. Mean ± SD is presented (versus sham-taVNS, *P < 0.05; versus baseline, ##P < 0.01). At baseline, both groups, n = 21. After treatment, taVNS group, n = 21; sham-taVNS group, n = 19. Pearson’s correlation analysis was performed to determine the correlation of the autonomic functions and CSBMs/week, VAS, and 5-HT in the taVNS group (before and after treatment, n = 42). HF, high-frequency band.