Skip to main content
. 2021 Jul 8;6(13):e146863. doi: 10.1172/jci.insight.146863

Figure 5. Gene expression signatures in the FCG murine neonatal lungs show striking correlation patterns superimposed on the human lung transcriptome.

Figure 5

To compare signatures (differentially expressed genes; DEGs) in our pulmonary murine models, we used transcriptome profiles of 578 healthy human adult lung samples compiled by the GTEx consortium to assess genotype/transcriptome relationships in phenotypically healthy individuals. We computed summed Z-scores for each human individual and each FCG signature and assessed intersignature correlations. (A) There is a clear separation between the P5 and the P21 hyperoxia signatures. The acute response signatures at P5 show very strong correlation across all genotypes. At P21, the hyperoxia responses in gonadal or chromosomal females XXF, XXM, and XYF cluster together, apart from the response in the chromosomal and gonadal male XYM genotype. (B–E) Correlation between genotype summed Z-scores are shown in room air at P5 (B) and P21 (C), and hyperoxia at P5 (D) and P21 (E).