Figure 6. Existing lymphatic valves regress in iLEC^Kras mice.

(A) Schematic showing when mice were fed tamoxifen (2 μl of 25 mg/ml solution). Tissues were collected on P14. (B and C) Whole-mount preps of mesentery from iLEC^Ctrl;mT/mG and iLEC^Kras;mT/mG mice. The arrows point to examples of a lymphatic valve. (D) iLEC^Ctrl;mT/mG mice had more lymphatic valves per mm lymphatic vessel length (0.9575 ± 0.1245; n = 4) than iLEC^Kras;mT/mG mice (0.07877 ± 0.04322; n = 3). Data are presented as mean ± SEM. **P < 0.01; unpaired Student’s t tests. Scale bar: 300 μm.