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. 2021 Jul 8;6(13):e138057. doi: 10.1172/jci.insight.138057

Figure 3. TALK-1 Leu114Pro hyperpolarizes the β cell Vm and prevents action potential firing.

Figure 3

(A–C) Vm was monitored from β cells transduced with either TALK-1 WT or TALK-1 Leu114Pro in response to 2 mM or 14 mM glucose, as indicated in the figure. TALK-1 Leu114Pro displayed 2 types of responses: (A) one that occurred only in a rare subset of cells and (B) one that was more typical. (D) Average resting and plateau Vm were calculated for TALK-1 Leu114Pro and TALK-1 WT (mean ± SEM; n = 10 control cells; n = 10 TALK-1 Leu114Pro cells; 1-way ANOVA followed by Bonferroni’s multiple comparison, ***P < 0.001).