Figure 6.
DAMP S100A8/A9 is persistently elevated in post-CLP mice and humans after sepsis-associated ALI. BAL, serum, and lung homogenate S100A8/A9 levels in 3-wk post-CLP mice and unoperated controls (A). Lung homogenate levels are normalized to total protein and expressed as picogram S100A8/A9 per µg total protein. Log10 plasma S100A8/A9 levels in human survivors (n = 12 patients) of sepsis (non-pulmonary; green) or pneumonia-induced ALI (white) as compared with healthy control (B). Mean ± SE shown, unpaired t test (A) or one-way ANOVA, post hoc Holm–Sidak P-value (B) shown *P < 0.05, **P < 0.01, ***P < 0.001. ALI, acute lung injury; BAL, bronchoalveolar lavage; CLP, cecal ligation and puncture; DAMP, damage-associated molecular pattern; Unop, unoperated.