Table 2.
KEGG pathway enrichment analysis of modules significantly associated with CLP
| Module Name | EGG Term | FDR | Genes in Module (n) | Genes in Term (n) | Gene Names |
|---|---|---|---|---|---|
| Modules positively correlated with CLP | |||||
| Purple | Natural killer cell-mediated cytotoxicity | 7.89E-05 | 11 | 113 | Ifng, Itgb2, Klra4, Lcp2, Klrb1c, Ncr1, Nfatc2, Vav1, Plcg2, Sh3bp2, Fcgr4 |
| Purple | Hematopoietic cell lineage | 7.89E-05 | 10 | 92 | Cd1d1, Cd34, Cd38, Cd4, Gp1ba, Itga2, Itga4, Itgb3, Kit, Kitl |
| Purple | Cell adhesion molecules (CAMs) | 4.04E-03 | 10 | 159 | Cd34, Cd4, H2-t24, Itga4, Itgb2, Sell, Lrrc4c, Icosl, Cadm1, Nectin3 |
| Purple | Chemokine signaling pathway | 1.39E-02 | 10 | 197 | Ccr3, Cx3cr1, Gng7, Hck, Lyn, Ncf1, Vav1, Grk6, Pik3r5, Ppbp |
| Darkred | Osteoclast differentiation | 6.91E-05 | 9 | 123 | Sirpb1c, Csf1r, Fosb, Il1b, Lilra6, Pirb, Spi1, Tyrobp, Sirpb1b |
| Darkred | NOD-like receptor signaling pathway | 6.91E-05 | 11 | 197 | Casp1, Casp4, Camp, Ifi204, Il1b, Naip6, Pstpip1, Nlrp3, Trpm2, Nlrp12, Mefv |
| Darkred | Staphylococcus aureus infection | 1.84E-02 | 5 | 87 | Camp, Itgam, Ptafr, Selp, Selplg |
| Darkred | IL-17 signaling pathway | 1.84E-02 | 5 | 90 | Fosb, Il1b, Mmp9, S100a8, S100a9 |
| Modules negatively correlated with CLP | |||||
| Plum | Protein processing in endoplasmic reticulum | 1.44E-02 | 5 | 162 | Hsph1, Hsp90ab1, Hsp90aa1, Ubqln1, Lman1 |
| Plum | IL-17 signaling pathway | 1.44E-02 | 4 | 90 | Srsf1, Fadd, Hsp90ab1, Hsp90aa1 |
| Salmon1 | Tryptophan metabolism | 4.35E-03 | 3 | 47 | Maob, Aox3, Aoc1 |
| Salmon1 | Fc-γ R-mediated phagocytosis | 4.53E-02 | 2 | 85 | Pld2, Amph |
Representative pathways are shown. CLP, cecal ligation and puncture; FDR, false discovery rate P-value; KEGG, Kyoto Encyclopedia of Genes and Genomes.