Table 1.
Summary of correlations analyses for hydroxyproline and fibrillar collagens (SHG) to percent affected lung tissue, and Muc5b protein and Muc5b gene expression to fibrillar collagens (SHG)
| 129S1/SvlmJ | A/J | CAST/EiJ | NZO/H1LtJ | NOD/ShiLtJ | PWK/PhJ | WSB/EiJ | C57BL/6J | |
|---|---|---|---|---|---|---|---|---|
| HP vs. %Affected | ||||||||
| Slope | 8.705 ± 5.095 | 3.556 ± 1.452 | 2.196 ± 4.671 | −14.83 ± 15.81 | 3.631 ± 5.155 | 11.44 ± 12.41 | 7.311 ± 3.781 | 7.453 ± 15.61 |
| Equation | Y = 8.705 * X + 139.8 | Y = 3.556 * X + 126.8 | Y = 2.196 * X + 145.2 | Y = −14.83 * X + 353.3 | Y = 3.631 * X + 180.4 | Y = 11.44 * X + 190.1 | Y = 7.311 * X + 126.8 | Y = 7.453 * X + 270.7 |
| R square | 0.3273 | 0.5452 | 0.02162 | 0.09903 | 0.0764 | 0.1241 | 0.2108 | 0.0366 |
| Spearman r | 0.4671 | 0.4286 | 0.03873 | -0.3161 | 0.3314 | 0.3703 | 0.2706 | 0.1807 |
| P (two-tailed) | 0.2471 | 0.3536 | 0.9073 | 0.3714 | 0.419 | 0.3643 | 0.3083 | 0.6722 |
| P value summary | ns | ns | ns | ns | ns | ns | ns | ns |
| SHG vs. %Affected | ||||||||
| Slope | 0.2684 ± 0.1157 | 0.265 ± 0.08014 | 0.0863 ± 0.09017 | 0.3868 ± 0.107 | 0.07755 ± 0.03909 | 0.01541 ± 0.1753 | 0.219 ± 0.04708 | 0.02983 ± 0.1201 |
| Equation | Y = 0.2684 * X + 1.27 | Y = 0.265 * X + 0.1228 | Y = 0.0863 * X + 1.31 | Y = 0.3868 * X + 0.05676 | Y = 0.07755 * X + 0.9012 | Y = 0.01541 * X + 1.224 | Y = 0.219 * X + 0.7457 | Y = 0.02983 * X + 1.699 |
| R square | 0.4729 | 0.6456 | 0.08392 | 0.6203 | 0.3961 | 0.001286 | 0.6073 | 0.01017 |
| Spearman r | 0.5868 | 0.8623 | 0.3134 | 0.8268 | 0.4542 | 0.08939 | 0.5576 | −0.03615 |
| P (two-tailed) | 0.1353 | 0.0089 | 0.3185 | 0.0047 | 0.2619 | 0.8286 | 0.0268 | 0.9429 |
| P value summary | ns | ** | ns | ** | ns | ns | * | ns |
| Muc5b pr vs. SHG | ||||||||
| Slope | 624.1 ± 1031 | −994.1 ± 2,480 | 433.1 ± 229 | −182.9 ± 1,783 | 9,647 ± 3,018 | −1,266 ± 2,035 | 3,413 ± 1,310 | 6,497 ± 4,199 |
| Equation | Y = 6,24.1 * X + 1,446 | Y = −994.1 * X + 9,848 | Y = 433.1 * X + 142.6 | Y = −182.9 * X + 9,341 | Y = 9,647 * X − 4,752 | Y = −1,266 * X + 4,235 | Y = 3,413 * X + 3,527 | Y = 6,497 * X − 1,661 |
| R square | 0.05758 | 0.02607 | 0.2845 | 0.001314 | 0.6301 | 0.07191 | 0.3264 | 0.3238 |
| Spearman r | 0.4524 | −0.3333 | 0.5545 | 0.006061 | 0.6667 | −0.1429 | 0.6353 | 0.4643 |
| P (two-tailed) | 0.2675 | 0.4279 | 0.0818 | >0.9999 | 0.0831 | 0.7825 | 0.0097 | 0.3024 |
| P value summary | ns | ns | ns | ns | ns | ns | ** | ns |
| Muc5b RNA vs. SHG | ||||||||
| Slope | 0.3599 ± 0.1655 | −0.1165 ± 0.1389 | −0.1749 ± 0.511 | −0.5903 ± 0.2049 | −1.412 ± 0.9965 | 2.156 ± 1.757 | 0.2059 ± 0.2898 | −0.1548 ± 0.481 |
| Equation | Y = 0.3599 * X + 3.016 | Y = −0.1165 * X + 6.093 | Y = −0.1749 * X + 1.287 | Y = −0.5903 * X + 6.463 | Y = −1.412 * X + 6.781 | Y = 2.156 * X + 2.016 | Y = 0.2059 * X + 4.131 | Y = −0.1548 * X + 6.383 |
| R square | 0.4409 | 0.105 | 0.01285 | 0.5092 | 0.2506 | 0.2007 | 0.03258 | 0.01696 |
| Spearman r | 0.619 | −0.5952 | 0.01818 | −0.5273 | −0.7619 | −0.04762 | 0.1887 | −0.3095 |
| P (two-tailed) | 0.115 | 0.1323 | 0.9673 | 0.1231 | 0.0368 | 0.9349 | 0.4668 | 0.4618 |
| P value summary | ns | ns | ns | ns | * | ns | ns | ns |
HP, hydroxyproline; ns, not significant; SHG, second-harmonic generation. *P < 0.05; **P < 0.005.