Table 1.

Baseline characteristics and physiology

	Animal No.	Age, yr	Sex	Weight, kg	RR	Temp, °C	SBP	DBP	HR, beats/min	Group
1	29564	7.5	Male	28.0	24	36.9	112	60	87	Dose finding
2	31202	5.0	Male	22.2	12	36.5	94	61	96	Dose finding
3	31210	5.0	Male	22.6	21	37.0	104	58	81	Dose finding
4	31032	5.4	Male	17.5	26	37.6	98	41	102	Dose finding
5	31022	5.5	Male	17.9	21	37.3	85	50	120	Dose finding
6	31207	5.2	Male	21.2	25	37.4	115	57	102	Dose finding and S. pneumoniae/Sham
7	31785	4.9	Male	24.5	17	37.4	113	64	90	Dose finding and S. pneumoniae/Sham
8	32307	4.9	Male	16.5	30	36.6	85	50	104	S. pneumoniae/Sham
9	31033	5.7	Male	20.4	40	37.4	93	49	91	S. pneumoniae/Sham
10	31065	5.9	Male	26.1	28	38.0	126	93	95	S. pneumoniae/Sham
11	31846	5.2	Male	22.0	28	38.3	84	41	104	S. pneumoniae/Sham
12	31135	5.6	Male	25.5	24	36.8	88	41	80	S. pneumoniae/Purification
13	31553	5.4	Male	22.2	24	37.4	107	47	77	S. pneumoniae/Purification
14	31113	5.6	Male	23.6	28	37.3	78	44	91	S. pneumoniae/Purification
15	31836	5.3	Male	19.6	20	36.9	95	62	81	S. pneumoniae/Purification
16	32539	4.5	Male	19.1	18	36.8	113	74	118	S. pneumoniae/Purification
17	31805	5.2	Male	22.7	21	37.7	96	48	89	S. pneumoniae/Purification
18	32552	4.6	Male	17.3	25	36.8	95	52	101	Uninfected/Purification
19	32298	5.0	Male	21.1	35	37.1	94	48	103	Uninfected/Purification
20	32215	5.2	Male	21.6	16	37.1	112	50	73	Uninfected/Purification
21	31322	5.1	Male	21.2	34	37.0	77	39	75	Uninfected/Purification

Two of the animals (31207 and 31785) were used for both the dose-finding study and the S. pneumoniae/Sham experiments. They were given heparin infusions for 4 h at the same time as the other S. pneumoniae/Sham animals but did not receive sham purification. DBP, diastolic blood pressure; HR, heart rate; RR, respiratory rate; SBP, systolic blood pressure; Temp, temperature.