Table 1.

Summary of disease scenarios simulated in this study

Disease Scenario	Description	Modeling Approach
Normotensive	Typical pulmonary vasculature	-Low stiffness -Minimal PVR
Case a: Lesions only	Mechanical obstructions due to ring- and web-like lesions	-90% area reduction in 9 ring-like lesions -0.009 permeability in 11 web-like lesions
Case b: Lesions with local remodeling	Increased vascular stiffness, narrowing of vessels distal to lesions, and increased PVR	-Increased stiffness in vessels distal to lesions -40% reduction in radius in vessels distal to lesions -Increase PVR in terminal vessels distal to lesions
Case c: Lesions with global small vessel arteriopathy	Narrowing, stiffening, and increased resistance in all small vessels	-40% reduction in radius in vessels with $A_0<5$ mm2 -Increased stiffness in narrowed vessels -Increased PVR in affected terminal vessels
Case d: Lesions with proximal remodeling and small vessel arteriopathy	Narrowing and stiffening of small vessels, dilation and stiffening of large proximal vessels, and increased PVR	-Small vessel remodeling from case c -Dilation of proximal arteries with $A_0\ge 10$ mm2 -Increased network stiffness -Increased PVR in all terminal vessels

PVR, pulmonary vascular resistance.