Fig. 1.

Spike protein monomers clustered according to similarity of ordered/disordered regions. The spike387 set is listed vertically according to similarity with chain A of 6zb4 (top). Order (yellow) and disorder (blue) are plotted, according to presence or absence of amino acid coordinates in the structure. A smaller vertical heat map indicates monomers with down (green) or up (white) RBD positions. A group of locked conformations that cluster with 6zb4 monomers is indicated. Amino acid sequence (horizontal) covers the extent of ordered regions in spike ectodomain structures, with specific regions of disorder noted along the top of the heat map. Domain structure of the spike protein is also shown, in register with the heat map. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)