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Individual residue contributions to locked / closed form differences. (a) For amino acids highlighted in Fig. 3c, both d-SASA and predicted pH 7.5 to 5 stability change are plotted as differences (locked – closed). (b) The presence of these residues in a set of coronaviruses that infect humans (other than SARS-CoV-2) is shown with a stacked histogram. For example, E132 is present only SARS-CoV-2, whilst D994 is also present in the other 6 viruses.
