TABLE 1.
Atm impact on tumor growth
| Genotype | % of apoptotic cellsa | % of S-phase cellsa | Type of CP neoplastic growth | No. of wks of survival (mean ± SE)b | Cause of death |
|---|---|---|---|---|---|
| Atm−/− | 0c | 0c | None | 20.2 ± 3.9 (6) | Thymoma |
| TgT121 | 100 | 100 | Slow | 31.0 ± 1.6 (16) | CP tumor |
| TgT121Atm+/− | 98c | 120c | Slow | 37.2 ± 4.21 (6) | CP tumor |
| TgT121Atm−/− | 107 ± 15 | 103 ± 33 | Slow | 22.7 ± 1.8 (15) | Thymoma |
| TgT121p53−/−d | 14 ± 10 | 109c | Rapid | 4 ± 0.2 (4) | CP tumor |
a
Relative to the level in TgT121 CP.
b
Values in parentheses are numbers of mice tested. Mean survival times of TgT121 and TgT121 Atm+/− mice are not significantly different (P = 0.1026 in an unpaired two-tailed t test). The difference may reflect background strain differences (TgT121 mice are C57BL/6 × DBA2; TgT121 Atm+/− mice are C57BL/6 × DBA2 × 129sv).
c
From a single sample.
d
Data from reference 34; TgT121 p53−/− mice are of a C57BL/6 × DBA2 × 129sv background.