Table 5.
Pharmacokinetic parameters of the four analytes in the normal and model group.
| Parameters | G-Rh1 | G-Rb1 | G-Rc | G-Rd |
|---|---|---|---|---|
| Normal | ||||
| Cmax (mg/L) | 15.163 ± 0.815 | 349.840 ± 6.238 | 7.741 ± 0.366 | 97.458 ± 1.800 |
| Tmax (h) | 0.50 ± 0.01 | 1.00 ± 0.01 | 1.00 ± 0.01 | 1.00 ± 0.01 |
| AUC 0-72 (mg/L∗h) | 128.871 ± 68.509 | 10399.870 ± 5196.010 | 228.760 ± 110.731 | 2061.658 ± 1011.618 |
| AUC 0-∞ (mg/L∗h) | 129.100 ± 68.507 | 10585.975 ± 5201.551 | 229.541 ± 110.102 | 2062.555 ± 1011.536 |
| t1/2 (h) | 10.731 ± 0.905 | 17.774 ± 0.207 | 9.659 ± 1.093 | 9.631 ± 0.206 |
| CLz/F (L/h/kg) | 621.227 ± 54.664 | 17.096 ± 0.382 | 647.808 ± 36.107 | 64.895 ± 2.255 |
| MRT (h) | 22.278 ± 10.621 | 15.952 ± 0.851 | 16.111 ± 2.798 | 13.997 ± 0.390 |
|
| ||||
| Model | ||||
| Cmax (mg/L) | 20.010 ± 1.027∗∗ | 385.694 ± 8.339∗ | 12.497 ± 0.809∗∗ | 104.959 ± 5.034 |
| Tmax (h) | 0.50 ± 0.01 | 1.00 ± 0.02 | 1.00 ± 0.01 | 1.00 ± 0.03 |
| AUC 0–72 (mg/L∗h) | 148.939 ± 62.329∗ | 26347.000 ± 13042.423∗ | 295.337 ± 165.908 | 2583.439 ± 1254.680∗ |
| AUC 0-∞ (mg/L∗h) | 149.172 ± 62.330∗ | 29419.304 ± 12850.460∗ | 295.641 ± 166.081 | 2587.285 ± 1253.860∗ |
| t1/2 (h) | 9.765 ± 0.825 | 13.472 ± 0.588∗∗ | 8.166 ± 0.881 | 10.198 ± 0.511 |
| CLz/F (L/h/kg) | 544.957 ± 6.150 | 11.994 ± 0.385∗ | 450.788 ± 23.974 | 55.744 ± 2.366∗∗ |
| MRT (h) | 16.589 ± 1.745 | 19.683 ± 0.793∗ | 14.639 ± 0.190 | 15.126 ± 0.671 |
Data were reported as mean ± SD for n = 6. ∗p < 0.05, ∗∗p < 0.01, compared with the normal group.